For research use only. Not for therapeutic Use.
Pimelic Diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (HDAC 1, 2, and 3, with IC50 values of 150 nM , 760nM, and 370 nM, respectively), demonstrating no activity against class II HDACs.
IC50 value: 150 nM (HDAC1), 370 nM (HDAC3), 760nM(HDAC2)
Target: HDAC
in vitro: Pimelic Diphenylamide 106 has preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1. Pimelic Diphenylamide 106 exhibits weaker inhibitory activities against HDAC 8 with IC50 of 5 μM after a 3-h preincubation with HDAC8.
| Catalog Number | I005568 |
| CAS Number | 937039-45-7 |
| Synonyms | N’-(2-aminophenyl)-N-(4-methylphenyl)heptanediamide |
| Molecular Formula | C20H25N3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H25N3O2/c1-15-11-13-16(14-12-15)22-19(24)9-3-2-4-10-20(25)23-18-8-6-5-7-17(18)21/h5-8,11-14H,2-4,9-10,21H2,1H3,(H,22,24)(H,23,25) |
| InChIKey | WTKBRPXPNAKVEQ-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)NC(=O)CCCCCC(=O)NC2=CC=CC=C2N |
| Reference | [1]. Chou CJ, et al. Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J Biol Chem. 2008 Dec 19;283(51):35402-35409. [2]. Xu C, et al. Chemical probes identify a role for histone deacetylase 3 in Friedreich’s ataxia gene silencing. Chem Biol. 2009 Sep 25;16(9):980-989. |
