Pimethixene maleate

• CAT Number: M061501
• CAS Number: 13187-06-9
• Molecular Formula: C23H23NO4S
• Molecular Weight: 409.50
• Purity: ≥95%
• Synonyms: (Z)-but-2-enedioic acid;1-methyl-4-thioxanthen-9-ylidenepiperidine
• InChI: InChI=1S/C19H19NS.C4H4O4/c1-20-12-10-14(11-13-20)19-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)19;5-3(6)1-2-4(7)8/h2-9H,10-13H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChIKey: IPANUAHQWFDVAG-BTJKTKAUSA-N
• SMILES: CN1CCC(=C2C3=CC=CC=C3SC4=CC=CC=C42)CC1.C(=CC(=O)O)C(=O)O

Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent.
Pimethixene maleate is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively[1].

Reference

[1]. Schmitz B, et al. BF-1–a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15;751:73-80.
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