For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>Pindolol (Cat.No:I001360) is a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial agonist / antagonist (Ki=33nM).</p>
| Catalog Number | I001360 |
| CAS Number | 13523-86-9 |
| Synonyms | (R)-1-((1H-indol-4-yl)oxy)-3-(isopropylamino)propan-2-ol |
| Molecular Formula | C14H20N2O2 |
| Purity | ≥95% |
| Target | Adrenergic Receptor |
| Solubility | 10 mM in DMSO |
| Storage | Store at RT |
| Reference | </br>1:NO-dependent attenuation of TPA-induced immunoinflammatory skin changes in Balb/c mice by pindolol, heptaminol or ATRA, but not by verapamil. Chung JF, Yoon CJ, Cheon SA, Seo ES, Park SH, Yang JS, Kim B, Joo MY, Park TJ, Kim KH, Sood AK, Lee SJ.Oncotarget. 2016 Jul 26;7(30):47576-47585. doi: 10.18632/oncotarget.10217. PMID: 27374093 Free PMC Article</br>2:The antihypertensive drug pindolol attenuates long-term but not short-term binge-like ethanol consumption in mice. Patkar OL, Belmer A, Holgate JY, Tarren JR, Shariff MR, Morgan M, Fogarty MJ, Bellingham MC, Bartlett SE, Klenowski PM.Addict Biol. 2017 May;22(3):679-691. doi: 10.1111/adb.12359. Epub 2016 Jan 11. PMID: 27273539 </br>3:Pindolol augmentation of selective serotonin reuptake inhibitors and clomipramine for the treatment of obsessive-compulsive disorder: A meta-analysis. Sassano-Higgins SA, Pato MT.J Pharmacol Pharmacother. 2015 Jan-Mar;6(1):36-8. doi: 10.4103/0976-500X.149144. No abstract available. PMID: 25709352 Free PMC Article</br>4:Is pindolol augmentation effective in depressed patients resistant to selective serotonin reuptake inhibitors? A systematic review and meta-analysis. Liu Y, Zhou X, Zhu D, Chen J, Qin B, Zhang Y, Wang X, Yang D, Meng H, Luo Q, Xie P.Hum Psychopharmacol. 2015 May;30(3):132-42. doi: 10.1002/hup.2465. Epub 2015 Feb 17. Review. PMID: 25689398 </br>5:Electroanalytical detection of pindolol: comparison of unmodified and reduced graphene oxide modified screen-printed graphite electrodes. Cumba LR, Smith JP, Brownson DA, Iniesta J, Metters JP, do Carmo DR, Banks CE.Analyst. 2015 Mar 7;140(5):1543-50. doi: 10.1039/c4an02005g. Epub 2015 Jan 22. PMID: 25610919 </br>6:Does Curcumin or Pindolol Potentiate Fluoxetine/’s Antidepressant Effect by a Pharmacokinetic or Pharmacodynamic Interaction? Murad HA, Suliaman MI, Abdallah H, Abdulsattar M.Indian J Pharm Sci. 2014 May;76(3):203-10. PMID: 25035531 Free PMC Article</br>7:Intermolecular complexation of low-molecular-weight succinoglycans directs solubility enhancement of pindolol. Kim K, Cho E, Choi JM, Kim H, Jang A, Choi Y, Lee IS, Yu JH, Jung S.Carbohydr Polym. 2014 Jun 15;106:101-8. doi: 10.1016/j.carbpol.2014.02.017. Epub 2014 Feb 15. PMID: 24721056 </br>8:Serial blood serotonin levels in a randomized controlled trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in patients with chronic tension-type facial pain. Agius AM, Jones NS, Muscat R.Rhinology. 2013 Sep;51(3):236-42. doi: 10.4193/Rhino13.019. PMID: 23943730 </br>9:Rational synthesis of pindolol imprinted polymer by non-covalent protocol based on computational approach. Tadi KK, Motghare RV.J Mol Model. 2013 Aug;19(8):3385-96. doi: 10.1007/s00894-013-1856-2. Epub 2013 May 18. PMID: 23686281 </br>10:A Randomized Controlled Trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in the treatment of chronic tension-type facial pain. Agius AM, Jones NS, Muscat R.Rhinology. 2013 Jun;51(2):143-53. doi: 10.4193/Rhino12.187. PMID: 23671895 |
