Pinostrobin

• CAT Number: R001877
• CAS Number: 480-37-5
• Purity: ≥95%
• Synonyms: (2S)-5-hydroxy-7-methoxy-2-phenyl-2,3-dihydrochromen-4-one
• InChI: InChI=1S/C16H14O4/c1-19-11-7-12(17)16-13(18)9-14(20-15(16)8-11)10-5-3-2-4-6-10/h2-8,14,17H,9H2,1H3/t14-/m0/s1
• InChIKey: ORJDDOBAOGKRJV-AWEZNQCLSA-N
• SMILES: COC1=CC(=C2C(=O)CC(OC2=C1)C3=CC=CC=C3)O

Pinostrobin is a flavonoid with anti-cancer, antioxidant, antiviral and neuroprotective activities. Pinostrobin has oral activity. Pinostrobin is a potent PCSK9 inhibitor that inhibits the catalytic activity of PCSK9. Pinostrobin can be used in the research of viral infections, cancer, leukemia, cardiovascular and cerebrovascular diseases, cirrhosis, inflammation and neurological diseases[1][2][3][4][5][6][7][8].
Pinostrobin (0-100 μg/mL, 72 h) inhibits HSV-1 virus, with the EC50 value of 22.71 μg/mL[2].
Pinostrobin (25-200 μM, 3 days) promotes melanin production in B16F10 cells by stimulating the expression of related melanin production regulatory factors in cAMP/PKA and p38 MAPK signaling pathways, and is non-toxic to cells[5]。
Pinostrobin (130 and 150 μM, 48 h) induces acute leukemia cell NB4 and MOLT-4 apoptosis via the regulation of miR-410-5p and SFRP5[6].
Pinostrobin (0-200 μM, 24-96 h) effectively induces apoptosis through ROS-mediated mitochondrial damage of cervical cancer cells (HeLa, Ca Ski, SiHa), and is not toxic to non-cancer cells HEK293 [7].
Pinostrobin (20 mg/kg , 50 mg/kg, i.g., daily for 7 days) delays the progression of lesions in a dose-dependent HSV-1 infected mouse model[2].
Pinostrobin (Single oral 10 and 20 mg/kg) has an anti-inflammatory effect by inhibiting TNF-α and IL-1β levels in rat models of LPS-induced inflammation [3].
Pinostrobin (daily oral 30 and 60 mg/kg for 2 months) has liver protective effect on liver cirrhosis induced by Thioacetamide (TAA) (HY-Y0698) in rats[4].
Relevant pharmacokinetic parameters of Pinostrobin in rats.[8]

Route
Dose (mg/kg)
AUC0-t (ng·min/mL)
MRT (h)
Cmax (ng/mL)
Tmax (h)
t1/2 (min)

i.g.
0.5
3817.80
6.26
615.35
4
4.34