Pioglitazone HCl

For research use only. Not for therapeutic Use.

  • CAT Number: A000405
  • CAS Number: 112529-15-4
  • Molecular Formula: C19H20N2O3S.HCl
  • Molecular Weight: 392.90
  • Purity: ≥95%
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Pioglitazone HCl(Cat No.:A000405)is a thiazolidinedione-class drug used primarily to treat type 2 diabetes. It works by activating peroxisome proliferator-activated receptor gamma (PPAR-γ), a nuclear receptor involved in regulating glucose and lipid metabolism. Through PPAR-γ activation, Pioglitazone increases insulin sensitivity in peripheral tissues, promoting glucose uptake and reducing blood sugar levels. Additionally, it helps improve lipid profiles by lowering triglycerides and increasing HDL cholesterol. Pioglitazone is commonly prescribed for managing hyperglycemia in patients with type 2 diabetes, often in combination with other antidiabetic medications to enhance therapeutic outcomes.


Catalog Number A000405
CAS Number 112529-15-4
Synonyms

AD-4833, U-72107E

Molecular Formula C19H20N2O3S.HCl
Purity ≥95%
Target Vitamin D Related/Nuclear Receptor
Solubility >19.7mg/mL in DMSO
Storage 3 years -20C powder
IUPAC Name 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydrochloride
InChI InChI=1S/C19H20N2O3S.ClH/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17;/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23);1H
InChIKey GHUUBYQTCDQWRA-UHFFFAOYSA-N
SMILES CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3.Cl
Reference

<p>
<span style=”color:#000000;”><span style=”font-size:12px;”><span style=”font-family:arial,helvetica,sans-serif;”>1.Sakamoto, Junichi, et al. &quot;Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>Biochemical and biophysical research communications</i>&nbsp;278.3 (2000): 704-711.<br />
2.Li, Xinbao, et al. &quot;Preferential solvation of pioglitazone hydrochloride in some binary co-solvent mixtures according to the inverse Kirkwood&ndash;Buff integrals method.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>The Journal of Chemical Thermodynamics</i>&nbsp;110 (2017): 218-226.<br />
3.Xing, Bin, et al. &quot;Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>Journal of Neuroinflammation</i>&nbsp;5.1 (2008): 1-11.<br />
4.Sugiyama, Y., et al. &quot;Effects of pioglitazone on glucose and lipid metabolism in Wistar fatty rats.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>Arzneimittel-forschung</i>&nbsp;40.3 (1990): 263-267.</span></span></span></p>

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