For research use only. Not for therapeutic Use.
Pioglitazone hydrochloride（Cat No.:I008770）is an oral antidiabetic medication belonging to the thiazolidinedione class, primarily used to manage type 2 diabetes. It enhances insulin sensitivity in muscle and adipose tissue by activating peroxisome proliferator-activated receptor gamma (PPAR-γ), leading to improved glucose uptake and lower blood sugar levels. In addition to its glycemic control effects, pioglitazone may have beneficial impacts on lipid profiles and cardiovascular health. However, it is associated with potential side effects, including weight gain and an increased risk of heart failure, warranting careful patient selection and monitoring during treatment.
| Catalog Number | I008770 |
| CAS Number | 112529-15-4 (HCl) |
| Synonyms | Pioglitazone Hydrochloride; Pioglitazone HCl; Actos; U-72107A; AD 4833; AD-4833; pioglitazone; pioglitazone hydrochloride; U 72107A; U-72107A; U72,107A;;5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydrochloride |
| Molecular Formula | C19H21ClN2O3S |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | -20°C |
| IUPAC Name | 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydrochloride |
| InChI | InChI=1S/C19H20N2O3S.ClH/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17;/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23);1H |
| InChIKey | GHUUBYQTCDQWRA-UHFFFAOYSA-N |
| SMILES | CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3.Cl |
| Reference | </br>1:Effects of vitamin D combined with pioglitazone hydrochloride on bone mineral density and bone metabolism in Type 2 diabetic nephropathy. Wang LX, Wang N, Xu QL, Yan W, Dong L, Li BL.Biosci Rep. 2017 Mar 27;37(2). pii: BSR20160544. doi: 10.1042/BSR20160544. Print 2017 Apr 28. PMID: 28153916 </br>2:[Pioglitazone hydrochloride a instrumental analytical perspective by Raman spectroscopy and HPLC]. Vértiz-Beltrán JF, Avila-Rodríguez R, Terrones-Gurrola R, Abelardo Camacho L, Rangel-López A, Campos-Cantón I, Vértiz-Hernández AA.Rev Invest Clin. 2014 Jul-Aug;66(4):351-8. Spanish. PMID: 25695301 </br>3:Design, statistical optimisation, characterisation and pharmacodynamic studies on Pioglitazone hydrochloride floating microparticles. Rao BP, Baby B, Mathews R, Rajarajan S, Haritha P, Ramesh K, Gupta NV.J Microencapsul. 2014;31(4):406-14. doi: 10.3109/02652048.2013.863399. Epub 2014 Apr 3. PMID: 24697182 </br>4:Pioglitazone hydrochloride: chemopreventive potential and development of site-specific drug delivery systems. Sinha VR, Sethi S.Drug Deliv. 2015 May;22(3):408-17. doi: 10.3109/10717544.2014.887156. Epub 2014 Feb 19. PMID: 24547712 </br>5:Formulation and Evaluation of Multilayered Tablets of Pioglitazone Hydrochloride and Metformin Hydrochloride. Chowdary YA, Raparla R, Madhuri M.J Pharm (Cairo). 2014;2014:848243. doi: 10.1155/2014/848243. Epub 2014 May 12. PMID: 26556204 Free PMC Article</br>6:Multivariate chemometric assisted analysis of metformin hydrochloride, gliclazide and pioglitazone hydrochloride in bulk drug and dosage forms. Bhaskar R, Bhaskar R, Sagar MK, Saini V.Adv Pharm Bull. 2013;3(1):79-84. doi: 10.5681/apb.2013.013. Epub 2013 Feb 7. PMID: 24312816 Free PMC Article</br>7:RP-HPLC method development and validation for simultaneous estimation of atorvastatin calcium and pioglitazone hydrochloride in pharmaceutical dosage form. Peraman R, Mallikarjuna S, Ammineni P, Kondreddy Vk.J Chromatogr Sci. 2014 Oct;52(9):1038-42. doi: 10.1093/chromsci/bmt156. Epub 2013 Oct 22. PMID: 24152592 </br>8:[Pharmacokinetic interaction of pioglitazone hydrochloride and atorvastatin calcium in Beagle dogs]. Chen HL, Zhang WP, Yang FY, Wang XY, Yang WC, Dang HW.Yao Xue Xue Bao. 2013 May;48(5):741-5. Chinese. PMID: 23888699 </br>9:RP-LC method for the simultaneous determination of gliquidone, pioglitazone hydrochloride, and atorvastatin in formulations and human serum. Mirza AZ, Arayne MS, Sultana N.J AOAC Int. 2013 Jan-Feb;96(1):56-9. PMID: 23513958 </br>10:In vitro-in vivo evaluation of fast-dissolving tablets containing solid dispersion of pioglitazone hydrochloride. Pandit V, Pai RS, Devi K, Suresh S.J Adv Pharm Technol Res. 2012 Jul;3(3):160-70. doi: 10.4103/2231-4040.101008. PMID: 23057002 Free PMC Article |
