Pioglitazone (potassium salt)

• CAT Number: R042230
• CAS Number: 1266523-09-4
• Molecular Formula: C19H19N2O3S • K
• Molecular Weight: 394.50
• Purity: ≥95%
• Synonyms: 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, monopotassium salt
• Storage: -20°C
• IUPAC Name: potassium;5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidin-3-ide-2,4-dione
• InChI: InChI=1S/C19H20N2O3S.K/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17;/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23);/q;+1/p-1
• InChIKey: YRUUYXLNBAJFIM-UHFFFAOYSA-M
• SMILES: CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)[N-]C(=O)S3.[K+]

Pioglitazone (potassium salt)（Cat No.:R042230）is an active pharmaceutical ingredient used primarily in the management of type 2 diabetes mellitus. It belongs to the thiazolidinedione class of medications, functioning as a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist. By enhancing insulin sensitivity in peripheral tissues, it helps regulate glucose metabolism and lower blood sugar levels. The potassium salt form improves solubility and bioavailability, facilitating effective absorption. Ongoing research is exploring its potential benefits beyond diabetes, including effects on cardiovascular health and lipid metabolism, highlighting its versatility in metabolic disorder management.

Reference

1.Willson, T.M.,Cobb, J.E.,Cowan, D.J., et al. The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J. Med. Chem. 39, 665-668 (1996).