For research use only. Not for therapeutic Use.
Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity[1][2].
Intravenously administered pipequaline exerts a partial suppression of activations by kainate, glutamate and acetylcholine. Microiontophoretic applications of pipequaline reduces the neuronal activation by kainate[2]. Pipequaline produces dose-related decreases in motor activity. Pipequaline produces significant dose-related decreases in the number of head-dips made[3].
| Catalog Number | I008772 |
| CAS Number | 77472-98-1 |
| Synonyms | 2-phenyl-4-(2-piperidin-4-ylethyl)quinoline |
| Molecular Formula | C22H24N2 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H24N2/c1-2-6-18(7-3-1)22-16-19(11-10-17-12-14-23-15-13-17)20-8-4-5-9-21(20)24-22/h1-9,16-17,23H,10-15H2 |
| InChIKey | AMEWZCMTSIONOX-UHFFFAOYSA-N |
| SMILES | C1CNCCC1CCC2=CC(=NC3=CC=CC=C32)C4=CC=CC=C4 |
| Reference | [1]. Bradwejn J, et al. Effects of PK 8165, a partial benzodiazepine receptor agonist, on cholecystokinin-inducedactivation of hippocampal pyramidal neurons: a microiontophoretic study in the rat. Eur J Pharmacol. 1985 Jun 19;112(3):415-8. [2]. Debonnel G, et al. Pipequaline acts as a partial agonist of benzodiazepine receptors: an electrophysiological study in the hippocampus of the rat. Neuropharmacology. 1987 Sep;26(9):1337-42. |
