Piperaquine tetraphosphate tetrahydrate

• CAT Number: I019288
• CAS Number: 915967-82-7
• Molecular Formula: C₂₉H₃₂Cl₂N₆.₄H₃O₄P.₄H₂O
• Molecular Weight: 999.60
• Purity: ≥95%
• Target: Parasite
• IUPAC Name: 7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline;phosphoric acid;tetrahydrate
• InChI: InChI=1S/C29H32Cl2N6.4H3O4P.4H2O/c30-22-2-4-24-26(20-22)32-8-6-28(24)36-16-12-34(13-17-36)10-1-11-35-14-18-37(19-15-35)29-7-9-33-27-21-23(31)3-5-25(27)29;4*1-5(2,3)4;;;;/h2-9,20-21H,1,10-19H2;4*(H3,1,2,3,4);4*1H2
• InChIKey: AMCQDGFOKTXHSY-UHFFFAOYSA-N
• SMILES: C1CN(CCN1CCCN2CCN(CC2)C3=C4C=CC(=CC4=NC=C3)Cl)C5=C6C=CC(=CC6=NC=C5)Cl.O.O.O.O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O

Piperaquine Tetraphosphate Tetrahydrate（Cat No.:I019288）is a bisquinoline antimalarial agent widely used in combination therapies to treat Plasmodium infections, including multidrug-resistant strains. It disrupts the parasite’s heme detoxification pathway, leading to toxic heme accumulation and parasite death. Combined with dihydroartemisinin, piperaquine enhances efficacy, providing long-lasting protection and reducing resistance development. Known for its extended half-life, it offers a simplified dosing regimen and is effective in both treatment and prevention. Its safety, potency, and role in artemisinin-based combination therapies make it a cornerstone in modern malaria control strategies.

Reference

[1]. Moore BR, et, al. Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model. Antimicrob Agents Chemother. 2008 Jan; 52(1): 306-11.[2]. Davis TME, et, al. Piperaquine: a resurgent antimalarial drug. Drugs. 2005; 65(1): 75-87.