Pirarubicin

• CAT Number: A000632
• CAS Number: 72496-41-4
• Molecular Formula: C32H37NO12
• Molecular Weight: 627.64
• Purity: ≥95%
• Synonyms: 72496-41-4; MFCD00869742; Theprubicin; THP-doxorubicin; C32H37NO12
• Target: Autophagy
• Solubility: >7.65mg/mL in DMSO
• Storage: -20°C
• IUPAC Name: (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-6-methyl-5-[(2R)-oxan-2-yl]oxyoxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
• InChI: InChI=1S/C32H37NO12/c1-14-31(45-21-8-3-4-9-42-21)17(33)10-22(43-14)44-19-12-32(40,20(35)13-34)11-16-24(19)30(39)26-25(28(16)37)27(36)15-6-5-7-18(41-2)23(15)29(26)38/h5-7,14,17,19,21-22,31,34,37,39-40H,3-4,8-13,33H2,1-2H3/t14-,17-,19-,21+,22-,31+,32-/m0/s1
• InChIKey: KMSKQZKKOZQFFG-YXRRJAAWSA-N
• SMILES: C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O[C@@H]6CCCCO6

Pirarubicin（Cat No.:A000632）is an anthracycline anticancer agent used in the treatment of various solid tumors, including breast cancer and bladder cancer. It works by intercalating into DNA, thereby inhibiting topoisomerase II, which prevents DNA replication and transcription, ultimately leading to cell death. Pirarubicin is a derivative of doxorubicin, but with reduced cardiotoxicity, making it a safer option in chemotherapy regimens. Its efficacy in inhibiting tumor growth, along with its relatively lower risk of heart-related side effects, makes it valuable in oncology for both research and clinical applications.

Reference

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