For research use only. Not for therapeutic Use.
Piromidic acid（Cat No.:I002497）is a potent compound used in the research of antimicrobial and anticancer therapies. It is primarily studied for its inhibitory effects on enzymes involved in nucleic acid synthesis. As an analog of uracil, Piromidic acid interferes with DNA replication, making it a candidate for developing novel treatments targeting cancer cells and microbial infections. Its mechanism of action and potential applications in drug discovery highlight its significance in biomedical research. Piromidic acid’s chemical structure and its bioactivity make it an important molecule in molecular pharmacology and therapeutics.
| Catalog Number | I002497 |
| CAS Number | 19562-30-2 |
| Molecular Formula | C14H16N4O3 |
| Purity | ≥95% |
| Target | Bacterial |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 8-ethyl-5-oxo-2-pyrrolidin-1-ylpyrido[2,3-d]pyrimidine-6-carboxylic acid |
| InChI | InChI=1S/C14H16N4O3/c1-2-17-8-10(13(20)21)11(19)9-7-15-14(16-12(9)17)18-5-3-4-6-18/h7-8H,2-6H2,1H3,(H,20,21) |
| InChIKey | RCIMBBZXSXFZBV-UHFFFAOYSA-N |
| SMILES | CCN1C=C(C(=O)C2=CN=C(N=C21)N3CCCC3)C(=O)O |
| Reference | </br>1:Square wave adsorptive stripping voltammetric determination of piromidic acid. Application in urine. Guiberteau Cabanillas A, Ortiz Burguillos JM, Martínez Cañas MA, Rodríguez Cáceres MI, Salinas López F.J Pharm Biomed Anal. 2003 Nov 24;33(4):553-62. PMID: 14623580 </br>2:Determination of piromidic acid residues in trout muscle tissue and in urine by liquid chromatography with post-column modification of pH and fluorimetric detection. Durán Merás I, Galeano Díaz T, Salinas López F, Rodríguez Cacéres MI.J Chromatogr B Biomed Sci Appl. 1998 Oct 23;718(1):135-41. PMID: 9832370 </br>3:Liquid chromatographic determination of flumequine, nalidixic acid, oxolinic acid, and piromidic acid residues in catfish (Ictalurus punctatus). Munns RK, Turnipseed SB, Pfenning AP, Roybal JE, Holland DC, Long AR, Plakas SM.J AOAC Int. 1998 Jul-Aug;81(4):825-38. PMID: 9680708 </br>4:[2 epidemics of acute kidney failure caused by piromidic acid]. Rostin M, Paux G, Sorbette F, Noblet C, Moore N, Boismare F, Montastruc P.Therapie. 1988 Aug-Sep;43(5):426-7. French. No abstract available. PMID: 3227506 </br>5:Simultaneous determination of nalidixic acid, oxolinic acid and piromidic acid in fish by high-performance liquid chromatography with fluorescence and UV detection. Horie M, Saito K, Hoshino Y, Nose N, Mochizuki E, Nakazawa H.J Chromatogr. 1987 Jul 31;402:301-8. PMID: 3654871 </br>6:Researches on antibacterial and antifungal agents. II – Synthesis of 1-ethyl-1,4-dihydro-4-oxo-7-(1-pyrrolidinyl)quinoline-3-carboxylic acid, a novel highly active, broad-spectrum antibacterial agent related to piromidic acid. Corelli F, Massa S, Stefancich G, Artico M, Panico S, Simonetti N.Farmaco Sci. 1984 Feb;39(2):95-109. PMID: 6425079 </br>7:[Acute renal failure after treatment with piromidic acid]. Godin M, Ducastelle T, Bercoff E, Dubois D, Fillastre JP, Bourreille J.Presse Med. 1983 May 14;12(21):1363-4. French. No abstract available. PMID: 6222321 </br>8:Activity of beta-hydroxy-piromidic acid against Staphylococcus aureus and enterobacteriaceae. García-Rodriguez JA, Gómez-García AC, Rodrigo N, Sáenz MC.J Antimicrob Chemother. 1982 Jun;9(6):493-5. No abstract available. PMID: 7107550 </br>9:Acute renal failure and piromidic acid. Rossi E, Silvestri MG, Manari A, Savazzi G, Migone L.Nephron. 1982;32(1):80-2. No abstract available. PMID: 7177284 </br>10:Formation of nitroso compounds and mutagens from cinnarizine, ethambutol, piromidic acid, pyridinol carbamate and tiaramide by drug/nitrite interaction. Takeda Y, Kanaya H.Cancer Lett. 1982 Jan;15(1):53-9. PMID: 7037170 |
