Piroxicam

• CAT Number: A000955
• CAS Number: 36322-90-4
• Molecular Formula: C15H13N3O4S
• Molecular Weight: 331.4
• Purity: ≥95%
• Synonyms: 36322-90-4; Feldene; Piroxicamum; Pyroxycam; Roxicam
• Target: COX
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• InChI: 1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)
• InChIKey: QYSPLQLAKJAUJT-UHFFFAOYSA-N
• SMILES: CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3

Piroxicam is a nonsteroidal anti-inflammatory drug. The mechanism of action of piroxicam is as a cyclooxygenase Inhibitor. It is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain.

Reference

1: Garofalo V, Ventura A, Mazzilli S, Diluvio L, Bianchi L, Toti L, Tisone G,
Milani M, Campione E. Treatment of Multiple Actinic Keratosis and Field of
Cancerization with Topical Piroxicam 0.8% and Sunscreen 50+ in Organ Transplant
Recipients: A Series of 10 Cases. Case Rep Dermatol. 2017 Oct 20;9(3):211-216.
doi: 10.1159/000481770. eCollection 2017 Sep-Dec. PubMed PMID: 29282394; PubMed
Central PMCID: PMC5731151.

2: Othman R, Vladisavljević GT, Simone E, Nagy ZK, Holdich RG. Preparation of
Microcrystals of Piroxicam Monohydrate by Antisolvent Precipitation via
Microfabricated Metallic Membranes with Ordered Pore Arrays. Cryst Growth Des.
2017 Dec 6;17(12):6692-6702. doi: 10.1021/acs.cgd.7b01307. Epub 2017 Nov 13.
PubMed PMID: 29234241; PubMed Central PMCID: PMC5722433.

3: Basiri Z, Zeraati F, Esna-Ashari F, Mohammadi F, Razzaghi K, Araghchian M,
Moradkhani S. Topical Effects of Artemisia Absinthium Ointment and Liniment in
Comparison with Piroxicam Gel in Patients with Knee Joint Osteoarthritis: A
Randomized Double-Blind Controlled Trial. Iran J Med Sci. 2017 Nov;42(6):524-531.
PubMed PMID: 29184260; PubMed Central PMCID: PMC5684373.

4: Jiménez JJ, Muñoz BE, Sánchez MI, Pardo R. Forced and long-term degradation
assays of tenoxicam, piroxicam and meloxicam in river water. Degradation products
and adsorption to sediment. Chemosphere. 2018 Jan;191:903-910. doi:
10.1016/j.chemosphere.2017.10.056. Epub 2017 Oct 25. PubMed PMID: 29145135.

5: Chinnaiyan S, Sarala N, Arun HS. A comparative study of efficacy and safety of
flupirtine versus piroxicam in postoperative pain in patients undergoing lower
limb surgery. J Pain Res. 2017 Oct 16;10:2471-2477. doi: 10.2147/JPR.S144647.
eCollection 2017. PubMed PMID: 29081669; PubMed Central PMCID: PMC5652919.

6: Panzade P, Shendarkar G, Shaikh S, Balmukund Rathi P. Pharmaceutical Cocrystal
of Piroxicam: Design, Formulation and Evaluation. Adv Pharm Bull. 2017
Sep;7(3):399-408. doi: 10.15171/apb.2017.048. Epub 2017 Sep 25. PubMed PMID:
29071222; PubMed Central PMCID: PMC5651061.

7: Ong SM, Saeki K, Kok MK, Tanaka Y, Choisunirachon N, Yoshitake R, Nishimura R,
Nakagawa T. Anti-tumour efficacy of etoposide alone and in combination with
piroxicam against canine osteosarcoma in a xenograft model. Res Vet Sci. 2017
Aug;113:130-135. doi: 10.1016/j.rvsc.2017.09.019. Epub 2017 Sep 19. PubMed PMID:
28957780.

8: Keiper NL, Cox SK, Doss GA, Elsmo B, Franzen-Klein D, Hartup BK.
PHARMACOKINETICS OF PIROXICAM IN CRANES (FAMILY GRUIDAE). J Zoo Wildl Med. 2017
Sep;48(3):886-890. doi: 10.1638/2016-0182.1. PubMed PMID: 28920805.

9: Calvo AM, Zupelari-Gonçalves P, Dionísio TJ, Brozoski DT, Faria FA, Santos CF.
Efficacy of piroxicam for postoperative pain after lower third molar surgery
associated with CYP2C8*3 and CYP2C9. J Pain Res. 2017 Jul 6;10:1581-1589. doi:
10.2147/JPR.S138147. eCollection 2017. PubMed PMID: 28740425; PubMed Central
PMCID: PMC5505550.

10: Goswami S, Sanyal S, Chakraborty P, Das C, Sarkar M. Interaction of a common
painkiller piroxicam and copper-piroxicam with chromatin causes structural
alterations accompanied by modulation at the epigenomic/genomic level. Biochim
Biophys Acta. 2017 Aug;1861(8):2048-2059. doi: 10.1016/j.bbagen.2017.04.006. Epub
2017 Apr 11. PubMed PMID: 28411076.