PIT-1

For research use only. Not for therapeutic Use.

  • CAT Number: I010676
  • CAS Number: 53501-41-0
  • Molecular Formula: C14H10ClN3O4S
  • Molecular Weight: 351.76
  • Purity: ≥95%
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PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo[1].


Catalog Number I010676
CAS Number 53501-41-0
Synonyms

N-[(3-chloro-2-hydroxy-5-nitrophenyl)carbamothioyl]benzamide

Molecular Formula C14H10ClN3O4S
Purity ≥95%
InChI InChI=1S/C14H10ClN3O4S/c15-10-6-9(18(21)22)7-11(12(10)19)16-14(23)17-13(20)8-4-2-1-3-5-8/h1-7,19H,(H2,16,17,20,23)
InChIKey RIGXBXPAOGDDIG-UHFFFAOYSA-N
SMILES C1=CC=C(C=C1)C(=O)NC(=S)NC2=C(C(=CC(=C2)[N+](=O)[O-])Cl)O
Reference

[1]. Miao B, et al. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20126-31.
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