PITCOIN3

• CAT Number: I047699
• CAS Number: 2397679-88-6
• Molecular Formula: C26H23N7O4S3
• Molecular Weight: 593.7
• Purity: ≥95%
• IUPAC Name: N-[4-[3-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-2-[4-oxo-3-(2-phenylethyl)pteridin-2-yl]sulfanylacetamide
• InChI: InChI=1S/C26H23N7O4S3/c1-40(36,37)32-19-9-5-8-18(14-19)20-15-38-25(29-20)30-21(34)16-39-26-31-23-22(27-11-12-28-23)24(35)33(26)13-10-17-6-3-2-4-7-17/h2-9,11-12,14-15,32H,10,13,16H2,1H3,(H,29,30,34)
• SMILES: CS(=O)(=O)NC1=CC=CC(=C1)C2=CSC(=N2)NC(=O)CSC3=NC4=NC=CN=C4C(=O)N3CCC5=CC=CC=C5

PITCOIN3 is a potent, highly selective and cell-permeable inhibitor of phosphatidylinositol 3-kinase C2α (PI3KC2α) with an IC50 value of 126 nM.
Keywords: PITCOIN3 | Supplier | PI3KC2α inhibitor | PITCOIN 3 | PITCOIN-3 | CAS [2397679-88-6] | Phosphatidylinositol | PI3K | Inhibitor | Enzymes | class II PI3K | Antithrombotic | Thrombosis

Reference

WT Lo et al. Development of selective inhibitors of phosphatidylinositol 3-kinase C2α. Nat Chem Biol. 2022 Sep 15.