For research use only. Not for therapeutic Use.
PITCOIN4 is a highly selective Class II Alpha PI3K-C2α inhibitor. PITCOIN4 shows nanomolar inhibition of PI3K-C2α and >100-fold selectivity in a general kinase panel[1].
| Catalog Number | I040279 |
| Synonyms | 2-[2-[[2-[4-oxo-3-(2-phenylethyl)pteridin-2-yl]sulfanylacetyl]amino]-1,3-thiazol-4-yl]-N-(2-phenylpropan-2-yl)acetamide |
| Molecular Formula | C30H29N7O3S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C30H29N7O3S2/c1-30(2,21-11-7-4-8-12-21)36-23(38)17-22-18-41-28(33-22)34-24(39)19-42-29-35-26-25(31-14-15-32-26)27(40)37(29)16-13-20-9-5-3-6-10-20/h3-12,14-15,18H,13,16-17,19H2,1-2H3,(H,36,38)(H,33,34,39) |
| InChIKey | WBXQHPRLMAYBJC-UHFFFAOYSA-N |
| SMILES | CC(C)(C1=CC=CC=C1)NC(=O)CC2=CSC(=N2)NC(=O)CSC3=NC4=NC=CN=C4C(=O)N3CCC5=CC=CC=C5 |
| Reference | [1]. Murat Kücükdisli, et al. Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition. J Med Chem. 2023 Oct 26;66(20):14278-14302. |
