For research use only. Not for therapeutic Use.
Pivampicillin Hydrochloride is the hydrochloride salt form of an orally active pivalate ester of ampicillin with antibacterial activity. Pivampicillin is hydrolyzed into its active form ampicillin by esterases. Ampicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.
| Catalog Number | R049604 |
| CAS Number | 26309-95-5 |
| Synonyms | (2S,5R,6R)-6-[[(2R)-2-Amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-?1-azabicyclo[3.2.0]heptane-2-carboxylic Acid (2,2-Dimethyl-1-oxopropoxy)methyl Ester Hydrochloride; Alphacilina; Alphacillin; Ampicillin Pivaloxyoxymethyl Ester Hydrochlorid |
| Molecular Formula | C₂₂H₃₀ClN₃O₆S |
| Purity | ≥95% |
| Storage | Desiccate at -80C |
| Reference | </br>1:Clinical trial of pivampicillin hydrochloride (alphacillin) in gonorrhoea [proceedings]. Alausa A, Osoba AO, Sogbetun AO.West Afr J Pharmacol Drug Res. 1976 Jun;3(1):70P. No abstract available. PMID: 1023509 </br>2:Clinical trial of pivampicillin hydrochloride (alphacillin) in gonorrhoea. Alausa KO, Osoba AO, Sogbetun AO.West Afr J Pharmacol Drug Res. 1976 Jun;3(1):31-7. PMID: 799402 </br>3:Acute gonococcal urethritis in males treated with a single oral dose of pivampicillin hydrochloride. Hunton RB, Harper RG, Bremner DA, Hookham AB.N Z Med J. 1974 Sep 11;80(523):205-8. No abstract available. PMID: 4530197 </br>4:Spectrophotometric determination of pivampicillin hydrochloride. Marchi E, Mascellani G, Boccali D.J Pharm Sci. 1974 Aug;63(8):1299-300. No abstract available. PMID: 4854359 </br>5:One-day oral pivampicillin hydrochloride treatment for acute gonococcal urethritis in male patients. Hunton RB, Harper RG, Bremner DA, Hookham AB.N Z Med J. 1974 May 8;79(514):907-8. No abstract available. PMID: 4212211 </br>6:[Spectrophotometric determination of pivampicillin hydrochloride]. Marchi E, Mascellani G, Boccali D.Farmaco Prat. 1973 Oct;28(10):523-8. Italian. No abstract available. PMID: 4769271 </br>7:Pivampicillin hydrochloride in uncomplicated gonorrhoea. Förström L, Lassus A.Br J Vener Dis. 1972 Dec;48(6):510-3. No abstract available. PMID: 4631231 Free PMC Article |
