PK68

• CAT Number: I018664
• CAS Number: 2173556-69-7
• Molecular Formula: C₂₂H₂₄N₄O₃S
• Molecular Weight: 424.52
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: cyclohexyl N-[5-(2-acetamido-1,3-benzothiazol-6-yl)-2-methylpyridin-3-yl]carbamate
• InChI: InChI=1S/C22H24N4O3S/c1-13-19(26-22(28)29-17-6-4-3-5-7-17)10-16(12-23-13)15-8-9-18-20(11-15)30-21(25-18)24-14(2)27/h8-12,17H,3-7H2,1-2H3,(H,26,28)(H,24,25,27)
• InChIKey: DRCNWQYEKZTTEW-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=N1)C2=CC3=C(C=C2)N=C(S3)NC(=O)C)NC(=O)OC4CCCCC4

PK68（Cat No.:I018664） is a selective and potent type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of approximately 90 nM. It inhibits RIPK1-dependent necroptosis and has the potential for use in the treatment of inflammatory disorders and cancer metastasis. PK68 ameliorates TNF-induced systemic inflammatory response syndrome with great efficacy.

Reference

[1]. Hou J, et al. Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis. Cell Death Dis. 2019 Jun 24;10(7):493.