PK9327

• CAT Number: I043844
• CAS Number: 2413987-20-7
• Molecular Formula: C21H22N2S
• Molecular Weight: 334.48
• Purity: ≥95%
• Synonyms: 1-[9-ethyl-7-(5-methylthiophen-2-yl)carbazol-3-yl]-N-methylmethanamine
• InChI: InChI=1S/C21H22N2S/c1-4-23-19-9-6-15(13-22-3)11-18(19)17-8-7-16(12-20(17)23)21-10-5-14(2)24-21/h5-12,22H,4,13H2,1-3H3
• InChIKey: AYQRLKNUUZAQQN-UHFFFAOYSA-N
• SMILES: CCN1C2=C(C=C(C=C2)CNC)C3=C1C=C(C=C3)C4=CC=C(S4)C

PK9327 is a small-molecule stabilizer targeting cavity-creating p53 cancer mutations.

Reference

[1]. Bauer MR, et al. Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm. ACS Chem Biol. 2020 Mar 20;15(3):657-668.
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