For research use only. Not for therapeutic Use.
PKC-theta inhibitor 1 is the PKCθ inhibitor with an Ki value of 6 nM, inhibits IL-2 production in vivo with an IC50 of 0.19 μM. PKC-theta inhibitor 1 demonstrates a reduction of symptoms in a mouse model of multiple sclerosis[1].
| Catalog Number | I018085 |
| CAS Number | 1160501-81-4 |
| Synonyms | [3-[3-[3-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-4-yl]phenyl]oxetan-3-yl]methanamine |
| Molecular Formula | C17H15F3N4O |
| Purity | ≥95% |
| InChI | InChI=1S/C17H15F3N4O/c18-17(19,20)14-13-12(4-5-22-15(13)24-23-14)10-2-1-3-11(6-10)16(7-21)8-25-9-16/h1-6H,7-9,21H2,(H,22,23,24) |
| InChIKey | WQSBBBAQXNAUEM-UHFFFAOYSA-N |
| SMILES | C1C(CO1)(CN)C2=CC=CC(=C2)C3=CC=NC4=NNC(=C34)C(F)(F)F |
| Reference | [1]. Collier PN, et al. Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase Cθ (PKCθ) That Ameliorate Symptoms of Experimental Autoimmune Encephalomyelitis. ACS Med Chem Lett. 2019 Jun 27;10(8):1134-1139. |
