PKC-theta inhibitor

• CAT Number: I019873
• CAS Number: 736048-65-0
• Molecular Formula: C20H25F3N6O3
• Molecular Weight: 454.45
• Purity: ≥95%
• Synonyms: 4-N-[[4-(aminomethyl)cyclohexyl]methyl]-5-nitro-2-N-[[2-(trifluoromethoxy)phenyl]methyl]pyrimidine-2,4-diamine
• InChI: InChI=1S/C20H25F3N6O3/c21-20(22,23)32-17-4-2-1-3-15(17)11-26-19-27-12-16(29(30)31)18(28-19)25-10-14-7-5-13(9-24)6-8-14/h1-4,12-14H,5-11,24H2,(H2,25,26,27,28)
• InChIKey: HKOWATVSFKRXRW-UHFFFAOYSA-N
• SMILES: C1CC(CCC1CN)CNC2=NC(=NC=C2[N+](=O)[O-])NCC3=CC=CC=C3OC(F)(F)F

PKC-theta inhibitor is a selective PKC-θinhibitor, with an IC50 of 12 nM.

Reference

[1]. Cywin CL, et al. Discovery of potent and selective PKC-theta inhibitors. Bioorg Med Chem Lett. 2007 Jan 1;17(1):225-30.
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