PKI(5-24)

• CAT Number: P000340
• CAS Number: 99534-03-9
• Molecular Formula: C94H148N32O31
• Molecular Weight: 2222.38
• Purity: ≥95%

PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor[1][2].
PKI(5-24) is a 20-residue peptide has been synthesized that corresponds to the active site of the skeletal muscle inhibitor protein[1].PKI(5-24) inhibits phosphotransferase activity of the mutant cGMP kinase with higher potency than that of wild type, with Ki values of 42 μΜ and 160 μΜ, respectively[2].

Reference

[1]. Cheng HC, et al. A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J Biol Chem. 1986;261(3):989-992.
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[2]. Ruth P, et al F. A cGMP kinase mutant with increased sensitivity to the protein kinase inhibitor peptide PKI(5-24). Biol Chem. 1996;377(7-8):513-520.
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