PKN1/2-IN-1

• CAT Number: I043973
• CAS Number: 942425-34-5
• Molecular Formula: C14H15N3O
• Molecular Weight: 241.29
• Purity: ≥95%
• Synonyms: 1-ethyl-2-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[3,2-c]pyridin-4-one
• InChI: InChI=1S/C14H15N3O/c1-2-17-12-5-8-16-14(18)11(12)9-13(17)10-3-6-15-7-4-10/h3-4,6-7,9H,2,5,8H2,1H3,(H,16,18)
• InChIKey: RVODROMIHSQWCT-UHFFFAOYSA-N
• SMILES: CCN1C2=C(C=C1C3=CC=NC=C3)C(=O)NCC2

PKN1/2-IN-1 is a potent, cell penetrant and selective PKN2 (PRK2) inhibitor (IC50=16 nM; Ki=8 nM)[1].

Reference

[1]. Scott F, et al. Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery. Bioorg Med Chem Lett. 2022;60:128588.
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