PKR activator 4

• CAT Number: I041289
• CAS Number: 2283420-05-1
• Molecular Formula: C18H24N6O2SSi
• Molecular Weight: 416.57
• Purity: ≥95%
• Synonyms: 7-methyl-4-[[1-(2-trimethylsilylethoxymethyl)pyrazol-3-yl]methyl]-3-thia-5,7,10,11-tetrazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),4,11-tetraen-9-one
• InChI: InChI=1S/C18H24N6O2SSi/c1-23-15-13(10-19-21-18(15)25)16-17(23)20-14(27-16)9-12-5-6-24(22-12)11-26-7-8-28(2,3)4/h5-6,10H,7-9,11H2,1-4H3,(H,21,25)
• InChIKey: OJINPWVFOQGLEV-UHFFFAOYSA-N
• SMILES: CN1C2=C(C=NNC2=O)C3=C1N=C(S3)CC4=NN(C=C4)COCC[Si](C)(C)C

PKR activator 4 (example 7A) is a potent pyruvate kinase R (PKR) activator. PKR activator 4 has the potential for the research of blood disorders[1].

Reference

[1]. Giovanni Cianchetta et al. Pyruvate kinase activators for use in treating blood disorders. WO2019035864A1.