For research use only. Not for therapeutic Use.
Pleconaril（Cat No.:I001915）is an antiviral drug primarily used to treat infections caused by enteroviruses and rhinoviruses, including the common cold and viral meningitis. It works by inhibiting viral replication through binding to the viral capsid, preventing the uncoating process required for viral RNA release and subsequent replication. Pleconaril has shown effectiveness against various picornaviruses, including enterovirus 71 (EV71), and has been explored for its potential in treating other viral infections. Though its clinical use has been limited, ongoing studies continue to assess its antiviral potential for respiratory and other viral diseases.
| Catalog Number | I001915 |
| CAS Number | 153168-05-9 |
| Molecular Formula | C18H18F3N3O3 |
| Purity | ≥95% |
| Target | Enterovirus |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20C |
| IUPAC Name | 3-[3,5-dimethyl-4-[3-(3-methyl-1,2-oxazol-5-yl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole |
| InChI | InChI=1S/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3 |
| InChIKey | KQOXLKOJHVFTRN-UHFFFAOYSA-N |
| SMILES | CC1=CC(=CC(=C1OCCCC2=CC(=NO2)C)C)C3=NOC(=N3)C(F)(F)F |
| Reference | </br>1:[A randomized, double-blind, placebo-controlled trial of pleconaril for the treatment of neonates with enterovirus sepsis]. Hernández M.Rev Chilena Infectol. 2016 Jun;33(3):359. doi: 10.4067/S0716-10182016000300021. Spanish. No abstract available. PMID: 27598292 Free Article</br>2:A Randomized, Double-Blind, Placebo-Controlled Trial of Pleconaril for the Treatment of Neonates With Enterovirus Sepsis. Abzug MJ, Michaels MG, Wald E, Jacobs RF, Romero JR, Sánchez PJ, Wilson G, Krogstad P, Storch GA, Lawrence R, Shelton M, Palmer A, Robinson J, Dennehy P, Sood SK, Cloud G, Jester P, Acosta EP, Whitley R, Kimberlin D; National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group..J Pediatric Infect Dis Soc. 2016 Mar;5(1):53-62. doi: 10.1093/jpids/piv015. Epub 2015 Apr 16. PMID: 26407253 Free PMC Article</br>3:In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses. Lacroix C, Laconi S, Angius F, Coluccia A, Silvestri R, Pompei R, Neyts J, Leyssen P.Virol J. 2015 Jul 14;12:106. doi: 10.1186/s12985-015-0330-4. PMID: 26169596 Free PMC Article</br>4:Exploration of the anti-enterovirus activity of a series of pleconaril/pirodavir-like compounds. Bernard A, Lacroix C, Cabiddu MG, Neyts J, Leyssen P, Pompei R.Antivir Chem Chemother. 2015 Apr;24(2):56-61. doi: 10.1177/2040206615589035. Epub 2015 Jun 11. PMID: 26071135 </br>5:Genetic and antigenic structural characterization for resistance of echovirus 11 to pleconaril in an immunocompromised patient. Benschop KS, Wildenbeest JG, Koen G, Minnaar RP, van Hemert FJ, Westerhuis BM, Pajkrt D, van den Broek PJ, Vossen AC, Wolthers KC.J Gen Virol. 2015 Mar;96(Pt 3):571-9. doi: 10.1099/vir.0.069773-0. Epub 2014 Nov 13. PMID: 25395595 </br>6:In-Silico screening of Pleconaril and its novel substituted derivatives with Neuraminidase of H1N1 Influenza strain. Hussain Basha S, Prasad RN.BMC Res Notes. 2012 Feb 17;5:105. doi: 10.1186/1756-0500-5-105. PMID: 22340192 Free PMC Article</br>7:Pleconaril revisited: clinical course of chronic enteroviral meningoencephalitis after treatment correlates with in vitro susceptibility. Wildenbeest JG, van den Broek PJ, Benschop KS, Koen G, Wierenga PC, Vossen AC, Kuijpers TW, Wolthers KC.Antivir Ther. 2012;17(3):459-66. doi: 10.3851/IMP1936. Epub 2011 Oct 24. PMID: 22293148 </br>8:In vitro and in vivo evaluation of ribavirin and pleconaril antiviral activity against enterovirus 71 infection. Zhang G, Zhou F, Gu B, Ding C, Feng D, Xie F, Wang J, Zhang C, Cao Q, Deng Y, Hu W, Yao K.Arch Virol. 2012 Apr;157(4):669-79. doi: 10.1007/s00705-011-1222-6. Epub 2012 Jan 15. PMID: 22245989 </br>9:Pleconaril-resistant chronic parechovirus-associated enteropathy in agammaglobulinaemia. van de Ven AA, Douma JW, Rademaker C, van Loon AM, Wensing AM, Boelens JJ, Sanders EA, van Montfrans JM.Antivir Ther. 2011;16(4):611-4. doi: 10.3851/IMP1792. PMID: 21685550 </br>10:New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3. Schmidtke M, Wutzler P, Zieger R, Riabova OB, Makarov VA.Antiviral Res. 2009 Jan;81(1):56-63. doi: 10.1016/j.antiviral.2008.09.002. Epub 2008 Oct 7. PMID: 18840470 |
