For research use only. Not for therapeutic Use.
Plerixafor (AMD3100) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively.<br>Plerixafor inhibits CXCL12-mediated chemotaxis with a potency lightly better than its affinity for CXCR4.<br>A single topical application of Plerixafor promotes wound healing in diabetic mice by increasing cytokine production, mobilizing bone marrow EPCs, and enhancing the activity of fibroblasts and monocytes/macrophages, thereby increasing both angiogenesis and vasculogenesis.
| Catalog Number | A000152 |
| CAS Number | 110078-46-1 |
| Synonyms | JM 3100 |
| Molecular Formula | C28H54N8 |
| Purity | ≥95% |
| Target | CXCR |
| Solubility | Limited solubility |
| Storage | 3 years -20C powder |
