Pleuromutilin

• CAT Number: I001024
• CAS Number: 125-65-5
• Molecular Formula: C22H34O5
• Molecular Weight: 378.50
• Purity: ≥95%
• Synonyms: 2-hydroxy-acetic acid-(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
• Target: Bacterial
• Solubility: 10 mM in DMSO
• Storage: Store at 4°C
• IUPAC Name: [(1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8]tetradecanyl] 2-hydroxyacetate
• InChI: InChI=1S/C22H34O5/c1-6-20(4)11-16(27-17(25)12-23)21(5)13(2)7-9-22(14(3)19(20)26)10-8-15(24)18(21)22/h6,13-14,16,18-19,23,26H,1,7-12H2,2-5H3/t13-,14+,16-,18+,19+,20-,21+,22+/m1/s1
• InChIKey: ZRZNJUXESFHSIO-BKUNHTPHSA-N
• SMILES: C[C@@H]1CC[C@@]23CCC(=O)[C@H]2[C@@]1([C@@H](C[C@@]([C@H]([C@@H]3C)O)(C)C=C)OC(=O)CO)C

Pleuromutilin（Cat No.:I001024）is a natural antibiotic derived from the mushroom Clitopilus passeckerianus, known for its selective activity against gram-positive bacteria. It works by binding to the bacterial 50S ribosomal subunit, inhibiting protein synthesis and effectively blocking bacterial growth. Pleuromutilin and its derivatives are widely used in veterinary medicine and are being explored for human use, particularly against drug-resistant pathogens like MRSA. In research, it plays a significant role in developing novel antibiotics, offering insights into ribosomal binding mechanisms and providing a promising approach to overcoming antibiotic resistance.

Reference

[1]. Shang RF et al. Synthesis and biological evaluation of new pleuromutilin derivatives as antibacterial agents. Molecules. 2014 Nov 19;19(11):19050-65.