For research use only. Not for therapeutic Use.
Plitidepsin（Cat No.:M115696）is a marine-derived cyclic peptide with potent antitumor activity, originally isolated from the sea squirt Aplidium albicans. It works by inhibiting protein synthesis and inducing apoptosis in cancer cells through the disruption of the eEF1A2 protein. Plitidepsin has shown efficacy in treating multiple myeloma and is being investigated for other malignancies. Its unique mechanism of action, combined with a favorable safety profile, positions it as a promising therapeutic option in oncology, particularly for patients with relapsed or refractory cancers. Ongoing clinical trials continue to explore its full potential.
| Catalog Number | M115696 |
| CAS Number | 137219-37-5 |
| Synonyms | aplidin; Aplidine; Dehydrodidemnin B |
| Molecular Formula | C57H87N7O15 |
| Purity | ≥95% |
| Target | Anti-infection |
| Storage | -20°C |
| IUPAC Name | (2S)-N-[(2R)-1-[[(3S,6S,8S,12S,13R,16S,17R,20S,23S)-13-[(2S)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-2,5,7,10,15,19,22-heptaoxo-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]amino]-4-methyl-1-oxopentan-2-yl]-N-methyl-1-(2-oxopropanoyl)pyrrolidine-2-carboxamide |
| InChI | InChI=1S/C57H87N7O15/c1-15-33(8)46-44(66)29-45(67)79-49(32(6)7)48(68)34(9)50(69)58-39(26-30(2)3)54(73)64-25-17-19-41(64)56(75)62(13)43(28-37-20-22-38(77-14)23-21-37)57(76)78-36(11)47(52(71)59-46)60-51(70)42(27-31(4)5)61(12)55(74)40-18-16-24-63(40)53(72)35(10)65/h20-23,30-34,36,39-44,46-47,49,66H,15-19,24-29H2,1-14H3,(H,58,69)(H,59,71)(H,60,70)/t33-,34-,36+,39-,40-,41-,42+,43-,44-,46+,47-,49-/m0/s1 |
| InChIKey | UUSZLLQJYRSZIS-LXNNNBEUSA-N |
| SMILES | CCC(C)C1C(CC(=O)OC(C(=O)C(C(=O)NC(C(=O)N2CCCC2C(=O)N(C(C(=O)OC(C(C(=O)N1)NC(=O)C(CC(C)C)N(C)C(=O)C3CCCN3C(=O)C(=O)C)C)CC4=CC=C(C=C4)OC)C)CC(C)C)C)C(C)C)O |
