PLpro inhibitor

• CAT Number: I000390
• CAS Number: 1093070-14-4
• Molecular Formula: C22H22N2O2
• Molecular Weight: 346.42
• Purity: ≥95%
• Synonyms: (Z)-5-((Z)-(1-hydroxyethylidene)amino)-2-methyl-N-((R)-1-(naphthalen-1-yl)ethyl)benzimidic acid
• Target: SARS-CoV
• Solubility: DMSO: ≥ 42 mg/mL
• Storage: Sealed in dry,Room Temperature
• IC50: 2.6 uM [1]
• IUPAC Name: 5-acetamido-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide
• InChI: InChI=1S/C22H22N2O2/c1-14-11-12-18(24-16(3)25)13-21(14)22(26)23-15(2)19-10-6-8-17-7-4-5-9-20(17)19/h4-13,15H,1-3H3,(H,23,26)(H,24,25)/t15-/m1/s1
• InChIKey: KGPYBLOBHQLIET-OAHLLOKOSA-N
• SMILES: CC1=C(C=C(C=C1)NC(=O)C)C(=O)NC(C)C2=CC=CC3=CC=CC=C32

Compound 6, known as a PLpro inhibitor（Cat No.:I000390）, is a highly potent inhibitor of the papain-like protease (PLpro)/deubiquitinase (DUBs) with an IC50 value of 2.6 μM and EC50 of 13.1 μM. It has been demonstrated that this compound can effectively prevent the replication of the SARS virus. With its strong inhibitory effects on PLpro, this compound may have potential as a therapeutic agent for the treatment of viral infections caused by coronaviruses.

Reference

[1]. Ratia, K., et al., A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A, 2008. 105(42): p. 16119-24.
[2]. http://www.google.com/patents/WO2010022355A1cl=en