For research use only. Not for therapeutic Use.
PluriSIn 1（Cat No.:I005449）is a selective inhibitor that targets the enzyme serotonin N-acetyltransferase, playing a key role in the maintenance and differentiation of pluripotent stem cells. By inhibiting this pathway, PluriSIn 1 helps eliminate undifferentiated stem cells, making it particularly useful in stem cell research and regenerative medicine. Its selective action on pluripotent cells reduces the risk of teratoma formation in therapeutic applications, promoting safer differentiation. PluriSIn 1 is an invaluable tool for advancing research in cell therapy and ensuring controlled stem cell development in vitro.
| Catalog Number | I005449 |
| CAS Number | 91396-88-2 |
| Synonyms | NSC 14613 |
| Molecular Formula | C₁₂H₁₁N₃O |
| Purity | ≥95% |
| Target | Dehydrogenase |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | N'-phenylpyridine-4-carbohydrazide |
| InChI | InChI=1S/C12H11N3O/c16-12(10-6-8-13-9-7-10)15-14-11-4-2-1-3-5-11/h1-9,14H,(H,15,16) |
| InChIKey | HUDWXDLBWRHCKO-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)NNC(=O)C2=CC=NC=C2 |
| Reference | </br>1:Postoperative CYFRA 21-1 and CEA as prognostic factors in patients with stage I pulmonary adenocarcinoma. He Y, Cui Y, Chang D, Wang T.Oncotarget. 2017 May 4. doi: 10.18632/oncotarget.17611. [Epub ahead of print] PMID: 28525894 </br>2:Discrete category of mother-to-infant bonding disorder and its identification by the Mother-to-Infant Bonding Scale: A study in Japanese mothers of a 1-month-old. Matsunaga A, Takauma F, Tada K, Kitamura T.Early Hum Dev. 2017 May 16;111:1-5. doi: 10.1016/j.earlhumdev.2017.04.008. [Epub ahead of print] PMID: 28525876 </br>3:Exploring the clonal evolution of CD133/aldehyde-dehydrogenase-1 (ALDH1)-positive cancer stem-like cells from primary to recurrent high-grade serous ovarian cancer (HGSOC). A study of the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) Consortium. Ruscito I, Cacsire Castillo-Tong D, Vergote I, Ignat I, Stanske M, Vanderstichele A, Ganapathi RN, Glajzer J, Kulbe H, Trillsch F, Mustea A, Kreuzinger C, Benedetti Panici P, Gourley C, Gabra H, Kessler M, Sehouli J, Darb-Esfahani S, Braicu EI.Eur J Cancer. 2017 May 16;79:214-225. doi: 10.1016/j.ejca.2017.04.016. [Epub ahead of print] PMID: 28525846 </br>4:/Expand and Click/: A New Method for Labeling HIV-1 Envelope Glycoproteins. Fernandez MV, Freed EO.Cell Chem Biol. 2017 May 18;24(5):548-550. doi: 10.1016/j.chembiol.2017.05.006. PMID: 28525770 </br>5:Book Review: Marijuana: The Unbiased Truth about the World/’s Most Popular Weed Marijuana: The Unbiased Truth about the World/’s Most Popular Weed . Hill Kevin P. . Center City (MN) : Hazelden Publishing ; 2015 . 205 p . CAD $20.99 . ISBN: 978-1-61649-559-6 . Berber M, Persad E.Can J Psychiatry. 2017 May;62(5):355. doi: 10.1177/0706743717700845. Epub 2017 Mar 29. No abstract available. PMID: 28525729 </br>6:Molecular Characterization of Prototheca strains isolated in China revealed the first cases of protothecosis associated with Prototheca zopfii genotype 1. Hirose N, Hua Z, Kato Y, Zhang Q, Li R, Nishimura K, Masuda M.Med Mycol. 2017 May 19. doi: 10.1093/mmy/myx039. [Epub ahead of print] PMID: 28525645 </br>7:Ros-Induced Store-Operated Ca2+ Entry Coupled to Parp-1 Hyperactivation is Independent of Parg Activity in Necrotic Cell Death. Munoz FM, Zhang F, Islas-Robles A, Lau SS, Monks TJ.Toxicol Sci. 2017 May 19. doi: 10.1093/toxsci/kfx106. [Epub ahead of print] PMID: 28525621 </br>8:Sulfatase-1 overexpression indicates poor prognosis in urothelial carcinoma of the urinary bladder and upper tract. Lee HY, Yeh BW, Chan TC, Yang KF, Li WM, Huang CN, Ke HL, Li CC, Yeh HC, Liang PI, Shiue YL, Wu WJ, Li CF.Oncotarget. 2017 May 3. doi: 10.18632/oncotarget.17590. [Epub ahead of print] PMID: 28525382 </br>9:The cell of origin dictates the temporal course of neurofibromatosis-1 (Nf1) low-grade glioma formation. Solga AC, Toonen JA, Pan Y, Cimino PJ, Ma Y, Castillon GA, Gianino SM, Ellisman MH, Lee DY, Gutmann DH.Oncotarget. 2017 May 3. doi: 10.18632/oncotarget.17589. [Epub ahead of print] PMID: 28525381 </br>10:Aquaporins 1, 3 and 8 expression in irritable bowel syndrome rats/’ colon via NF-κB pathway. Chao G, Zhang S.Oncotarget. 2017 May 2. doi: 10.18632/oncotarget.17565. [Epub ahead of print] PMID: 28525373 |
