For research use only. Not for therapeutic Use.
PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs)[1].
PluriSIn #2 (20 µM; 12 hours) treatment reduces TOP2A expression at the protein level[1].
A 24h exposure of PluriSIn #2 (20 µM) is sufficient to induce massive cell death in hPSCs, but doesn’t affect the viability of various other cell types derived from them[1].
| Catalog Number | I045623 |
| CAS Number | 56563-17-8 |
| Synonyms | 5-fluoro-2,4-dioxo-N-phenylpyrimidine-1-carboxamide |
| Molecular Formula | C11H8FN3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C11H8FN3O3/c12-8-6-15(11(18)14-9(8)16)10(17)13-7-4-2-1-3-5-7/h1-6H,(H,13,17)(H,14,16,18) |
| InChIKey | PXXNTSRWKSCFCK-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)NC(=O)N2C=C(C(=O)NC2=O)F |
| Reference | [1]. Uri Ben-David, et al. Brief reports: Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha. Stem Cells. 2015 Mar;33(3):1013-9. |
