PLX-4032

• CAT Number: A000179
• CAS Number: 918504-65-1
• Molecular Formula: C₂₃H₁₈ClF₂N₃O₃S
• Molecular Weight: 489.92
• Purity: ≥95%
• Synonyms: RO5185426
• Target: MEK1/2
• Solubility: >24.5mg/mL in DMSO
• IUPAC Name: N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide
• InChI: InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)
• InChIKey: GPXBXXGIAQBQNI-UHFFFAOYSA-N
• SMILES: CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)F

PLX-4032 (also known as Vemurafenib)（Cat No.:A000179）is a selective inhibitor of the BRAF V600E mutation, a common mutation found in various cancers, particularly melanoma. By targeting this mutated form of BRAF, PLX-4032 disrupts the MAPK/ERK signaling pathway, leading to reduced cell proliferation and increased apoptosis in cancer cells. It has been used in the treatment of melanoma with BRAF mutations, showing significant clinical efficacy. PLX-4032 is a critical tool in cancer research and drug development, particularly for exploring targeted therapies in BRAF-mutant tumors.

Reference

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