PM-1

• CAT Number: I040559
• CAS Number: 1449483-78-6
• Molecular Formula: C16H14N2O2S
• Molecular Weight: 298.36
• Purity: ≥95%
• Synonyms: 3-[4-(1,3-benzothiazol-2-yl)anilino]propanoic acid
• InChI: InChI=1S/C16H14N2O2S/c19-15(20)9-10-17-12-7-5-11(6-8-12)16-18-13-3-1-2-4-14(13)21-16/h1-8,17H,9-10H2,(H,19,20)
• InChIKey: PWKDNGQJVGZGED-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)N=C(S2)C3=CC=C(C=C3)NCCC(=O)O

PM-1, a derivative of Thioflavin-T (ThT; HY-D0218), is a small but highly specific plasma membrane (PM) fluorescent dye for specific and long-time membrane imaging of living and fixed cells. PM-1 is embedded directly into the cell membrane and exhibits a very long retention time on the plasma membrane with a half-life of approximately 15 h. PM-1 can be used in combination with protein labeling probes to study ectodomain shedding and endocytosis processes of cell surface proteins[1].

Reference

[1]. Shun-Qiang Xu, et al. Small Plasma Membrane-Targeted Fluorescent Dye for Long-Time Imaging and Protein Degradation Analyses. nal Chem. 2023 Oct 24;95(42):15549-15555.
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