For research use only. Not for therapeutic Use.
PMX-53(CAT: I008792) is a compound that acts as a dual antagonist and agonist, targeting the C5a receptor (C5aR or CD88) and the Mas-related gene 2 (MrgX2) receptor. By acting as a C5aR antagonist, PMX-53 can inhibit the hypernociception induced by C5a in rats. Additionally, it has shown inhibitory effects on lung metastasis in a mouse model of breast cancer and has demonstrated the ability to reduce atherosclerotic lesions in a mouse model of atherosclerosis. These properties make PMX-53 a promising candidate for potential therapeutic applications in pain management, cancer treatment, and cardiovascular diseases.
| Catalog Number | I008792 |
| CAS Number | 219639-75-5 |
| Synonyms | PMX 53; PMX 53; PMX53; Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg); AcPhe(ornithine-Pro-cyclohexylamine-Trp-Arg. AcPhe(ornithine-Pro-cyclohexylamine-Trp-Arg);(S)-N-((3R,6S,9S,15S,20aS)-6-((1H-indol-3-yl)methyl)-3-(cyclohexylmethyl)-9-(3-guanidinopropyl)-1, |
| Molecular Formula | C47H65N11O7 |
| Purity | ≥95% |
| Target | Complement System |
| Solubility | Soluble in DMSO |
| Storage | -20°C |
| Overview of Clinical Research | <span style=”color:#000000;”><span style=”font-size:12px;”><span style=”font-family:arial,helvetica,sans-serif;”>PMX-53 is a complement C5a inhibitor. It has not been granted for the orphan drug status.</span></span></span> |
| IUPAC Name | (2S)-2-acetamido-N-[(3S,9S,12S,15R,18S)-15-(cyclohexylmethyl)-9-[3-(diaminomethylideneamino)propyl]-12-(1H-indol-3-ylmethyl)-2,8,11,14,17-pentaoxo-1,7,10,13,16-pentazabicyclo[16.3.0]henicosan-3-yl]-3-phenylpropanamide |
| InChI | InChI=1S/C47H65N11O7/c1-29(59)53-37(25-30-13-4-2-5-14-30)42(61)55-36-20-11-22-50-41(60)35(19-10-23-51-47(48)49)54-44(63)39(27-32-28-52-34-18-9-8-17-33(32)34)56-43(62)38(26-31-15-6-3-7-16-31)57-45(64)40-21-12-24-58(40)46(36)65/h2,4-5,8-9,13-14,17-18,28,31,35-40,52H,3,6-7,10-12,15-16,19-27H2,1H3,(H,50,60)(H,53,59)(H,54,63)(H,55,61)(H,56,62)(H,57,64)(H4,48,49,51)/t35-,36-,37-,38+,39-,40-/m0/s1 |
| InChIKey | YOKBGCTZYPOSQM-HPSWDUTRSA-N |
| SMILES | CC(=O)NC(CC1=CC=CC=C1)C(=O)NC2CCCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C3CCCN3C2=O)CC4CCCCC4)CC5=CNC6=CC=CC=C65)CCCN=C(N)N |
| Reference | <br /> |
