pNP-ADPr disodium

• CAT Number: I040836
• Molecular Formula: C21H24N6Na2O16P2
• Molecular Weight: 724.37
• Purity: ≥95%
• Synonyms: disodium;[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [(2R,3S,4R,5S)-3,4-dihydroxy-5-(4-nitrophenoxy)oxolan-2-yl]methyl phosphate
• IUPAC Name: disodium;[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [(3R,4S)-3,4-dihydroxy-5-(4-nitrophenoxy)oxolan-2-yl]methyl phosphate
• InChI: InChI=1S/C21H26N6O16P2.2Na/c22-18-13-19(24-7-23-18)26(8-25-13)20-16(30)14(28)11(41-20)5-38-44(34,35)43-45(36,37)39-6-12-15(29)17(31)21(42-12)40-10-3-1-9(2-4-10)27(32)33;;/h1-4,7-8,11-12,14-17,20-21,28-31H,5-6H2,(H,34,35)(H,36,37)(H2,22,23,24);;/q;2*+1/p-2/t11-,12-,14-,15-,16-,17-,20-,21-;;/m1../s1
• InChIKey: NQOVHENPPPWLBJ-AKTZONNESA-L
• SMILES: C1=CC(=CC=C1[N+](=O)[O-])OC2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O.[Na+].[Na+]

pNP-ADPr disodium (para-Nitrophenyl ADP-ribose disodium salt)(CAT: I040836) is a chromogenic substrate commonly used in enzymatic assays to study ADP-ribosylation processes. It is particularly useful for investigating the activity of ADP-ribosyl hydrolases and related enzymes involved in DNA repair, cellular stress responses, and signaling pathways. The para-nitrophenyl group allows for easy spectrophotometric detection, enabling quantitative analysis of enzymatic activity. pNP-ADPr disodium offers high purity, stability, and water solubility, making it ideal for biochemical and molecular biology research. Its application supports the development of therapeutic strategies targeting ADP-ribosylation in cancer, inflammation, and neurodegenerative diseases.