PNR-7-02

• CAT Number: I034905
• CAS Number: 1633660-76-0
• Molecular Formula: C24H16ClN3O2S
• Molecular Weight: 445.92
• Purity: 98%
• Synonyms: PNR-7-02; PNR702; PNR 7 02; PNR-702; PNR7-02; PNR 7-02; PNR-7 02
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 5-((5-Chloro-1-(naphthalen-2-ylmethyl)-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
• InChI: InChI=1S/C24H16ClN3O2S/c25-18-7-8-21-19(11-18)17(10-20-22(29)26-24(31)27-23(20)30)13-28(21)12-14-5-6-15-3-1-2-4-16(15)9-14/h1-11,13H,12H2,(H2,26,27,29,30,31)
• InChIKey: YNPDEEPROJUWCY-UHFFFAOYSA-N
• SMILES: O=C(/C(C(N1)=O)=CC2=CN(CC3=CC=C4C=CC=CC4=C3)C5=C2C=C(Cl)C=C5)NC1=S

PNR-7-02(CAT: I034905) is a selective inhibitor of human DNA polymerase eta (Polη), an enzyme involved in translesion DNA synthesis and the repair of UV-induced DNA damage. By targeting Polη, PNR-7-02 disrupts error-prone DNA repair pathways, making it a valuable tool for studying genomic stability and the mechanisms underlying DNA damage tolerance. It is particularly relevant in cancer research, where Polη plays a role in chemoresistance and mutagenesis. With its high specificity and potency, PNR-7-02 supports preclinical studies aimed at understanding DNA repair processes and developing novel therapeutic strategies targeting Polη-associated pathways.