For research use only. Not for therapeutic Use.
PNU-120596(CAT: I003767) is a potent and selective positive allosteric modulator of α7 nicotinic acetylcholine receptors (α7 nAChRs). By enhancing receptor sensitivity and prolonging channel activation, PNU-120596 facilitates cholinergic signaling without directly activating the receptor. This compound has been extensively studied for its neuroprotective and cognitive-enhancing effects, making it a valuable tool in research on neurodegenerative diseases such as Alzheimer’s disease and schizophrenia. Its specificity for α7 nAChRs enables detailed exploration of receptor function, synaptic plasticity, and therapeutic strategies targeting cholinergic deficits in neurological and psychiatric disorders.
| Catalog Number | I003767 |
| CAS Number | 501925-31-1 |
| Synonyms | 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-1,2-oxazol-3-yl)urea |
| Molecular Formula | C13H14ClN3O4 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | DMSO ≥60mg/mL Water <1.2mg/mL Ethanol ≥1.2mg/mL |
| Storage | 3 years -20C powder |
| IC50 | 0.2 uM (EC50) |
| IUPAC Name | 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-1,2-oxazol-3-yl)urea |
| InChI | InChI=1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18) |
| InChIKey | CEIIEALEIHQDBX-UHFFFAOYSA-N |
| SMILES | CC1=CC(=NO1)NC(=O)NC2=CC(=C(C=C2OC)OC)Cl |
