For research use only. Not for therapeutic Use.
Potent 5-HT2 ligand (Ki values 18 nM, 18 nM, and 66 nM for 5-HT2A, 5-HT2C, and 5-HT2B, respectively). PNU 22394 is virtually a full agonist at 5-HT2C receptors (87% of 5-HT), but a partial agonist at 5-HT2A (65% of 5-HT), and 5-HT2B (<15% of 5-HT) receptors, and produced a dose-related decrease in food consumption compared to saline-treated control rats. KEYWORDS: PNU 22394 hydrochloride | supplier | 5-HT2C agonist | PNU22394 | PNU 22394A | CAS [15923-42-9] | [15923-78-1] | Serotonin | 5-HT2C | Agonist | 5-HT2A | 5-HT2B | food | consumption | obesity | weight loss | metabolism | hypophagic | anorexogenic
| Catalog Number | I010524 |
| CAS Number | 15923-42-9 |
| Molecular Formula | C13H16N2.HCl |
| Purity | ≥95% |
| IUPAC Name | 6-methyl-2,3,4,5-tetrahydro-1H-azepino[4,5-b]indole;hydrochloride |
| InChI | InChI=1S/C13H16N2.ClH/c1-15-12-5-3-2-4-10(12)11-6-8-14-9-7-13(11)15;/h2-5,14H,6-9H2,1H3;1H |
| SMILES | CN1C2=C(CCNCC2)C3=CC=CC=C31.Cl |
| Reference | Dunlop, j. et al. WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor-selective agonist with anorectic activity. J. Pharmacol. Exp. Ther. 2005, 313(2), 862-869.
Bishop, M.J. et al. New 5-HT2C receptor agonists Expert Opin. Ther. Patents 2003, 13 (11), 1691-1705.
RB McCall et al. PNU-22394, a 5-HT2C receptor agonist, reduces feeding in rodents and produces weight loss in humans. Neuroscience 2001 Abstract, Presentation Number: 309.2 |
