For research use only. Not for therapeutic Use.
PNU 282987 is a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs; K<sub>i</sub> = 26 nM for the rat receptor). It has negligible activity against α1β1γδ and α3β4 nAChRs as well as a panel of monoamine, muscarinic, glutamate, and GABA receptors, except 5-HT<sub>3</sub> (K<sub>i</sub> = 930 nM). PNU 282987 evokes whole-cell currents from cultured rat hippocampal neurons and enhances GABAergic synaptic activity when applied to hippocampal slices.
| Catalog Number | R065545 |
| CAS Number | 711085-63-1 |
| Synonyms | N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-benzamide |
| Molecular Formula | C14H17ClN2O |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| IUPAC Name | N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide |
| InChI | InChI=1S/C14H17ClN2O/c15-12-3-1-11(2-4-12)14(18)16-13-9-17-7-5-10(13)6-8-17/h1-4,10,13H,5-9H2,(H,16,18)/t13-/m0/s1 |
| InChIKey | WECKJONDRAUFDD-ZDUSSCGKSA-N |
| SMILES | C1CN2CCC1C(C2)NC(=O)C3=CC=C(C=C3)Cl |
| Reference | 1.Bodnar, A.L.,Cortes-Burgos, L.A.,Cook, K.K., et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors. J. Med. Chem. 48(4), 905-908 (2005). |
