PNU-74654

• CAT Number: I013744
• CAS Number: 113906-27-7
• Molecular Formula: C₁₉H₁₆N₂O₃
• Molecular Weight: 320.34
• Purity: ≥95%
• Target: Apoptosis
• Solubility: DMSO: ≥ 30 mg/mL
• IUPAC Name: N-[(E)-(5-methylfuran-2-yl)methylideneamino]-2-phenoxybenzamide
• InChI: InChI=1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+
• InChIKey: JJEDWBQZCRESJL-DEDYPNTBSA-N
• SMILES: CC1=CC=C(O1)/C=N/NC(=O)C2=CC=CC=C2OC3=CC=CC=C3

PNU-74654（Cat No.:I013744）is a selective small molecule antagonist of the metabotropic glutamate receptor 5 (mGluR5), a G-protein-coupled receptor involved in synaptic plasticity, learning, and memory. By blocking mGluR5, PNU-74654 has been investigated for its potential therapeutic applications in neurological disorders such as Alzheimer’s disease, Parkinson’s disease, and anxiety. It may help modulate glutamatergic signaling, reducing excitotoxicity and improving cognitive function. Preclinical studies suggest it could have neuroprotective effects, but further research is required to evaluate its safety, efficacy, and potential clinical applications in treating neurological and psychiatric conditions.