PNU-74654

• CAT Number: R062455
• CAS Number: 113906-27-7
• Molecular Formula: C₁₉H₁₆N₂O₃
• Molecular Weight: 320.34
• Purity: ≥95%
• Synonyms: 2-Phenoxybenzoic Acid [(5-Methyl-2-furanyl)methylene]hydrazide
• Target: Wnt/β-catenin
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at +4℃
• InChI: InChI=1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)
• InChIKey: JJEDWBQZCRESJL-UHFFFAOYSA-N
• SMILES: CC1=CC=C(O1)C=NNC(=O)C2=CC=CC=C2OC3=CC=CC=C3

PNU-74654 is a selective, potent inhibitor of the PI3Kδ isoform, a key regulator of immune cell function. It has shown promise in preclinical studies for modulating immune responses, particularly in treating inflammatory diseases and certain types of cancer, where PI3Kδ plays a critical role in cell survival, proliferation, and migration. Research is ongoing to explore its potential for autoimmune disorders, such as rheumatoid arthritis, and for enhancing the efficacy of cancer immunotherapy.