PNU112455A hydrochloride

• CAT Number: I016677
• CAS Number: 21886-12-4
• Molecular Formula: C₁₀H₁₂ClN₅O₂S
• Molecular Weight: 301.75
• Purity: ≥95%
• Storage: 2-8°C
• IUPAC Name: 4-[(6-aminopyrimidin-4-yl)amino]benzenesulfonamide;hydrochloride
• InChI: InChI=1S/C10H11N5O2S.ClH/c11-9-5-10(14-6-13-9)15-7-1-3-8(4-2-7)18(12,16)17;/h1-6H,(H2,12,16,17)(H3,11,13,14,15);1H
• InChIKey: XBXQRCJKDCEQBS-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1NC2=NC=NC(=C2)N)S(=O)(=O)N.Cl

PNU112455A hydrochloride（Cat No.:I016677）is a selective antagonist of the adenosine A2A receptor, which plays a key role in modulating neurotransmitter release and immune responses. By blocking the A2A receptor, PNU112455A has potential applications in neurodegenerative disease research, particularly in Parkinson’s disease, where A2A receptor antagonists can help improve motor function by enhancing dopamine signaling. Additionally, its effects on the immune system have made it of interest in oncology, where A2A receptor blockade can enhance immune responses against tumors. PNU112455A is valuable in studying the therapeutic potential of A2A receptor inhibition.

Reference

[1]. Clare PM, et al. The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism. J Biol Chem. 2001 Dec 21;276(51):48292-9.