For research use only. Not for therapeutic Use.
Pocapavir（Cat No.:I008810）is an investigational antiviral agent targeting enteroviruses, including poliovirus, making it a valuable tool in virology research. It functions by binding to the viral capsid, stabilizing its structure, and preventing the uncoating process necessary for viral replication. Pocapavir’s unique mechanism offers potential for studying capsid-targeting therapies and understanding viral resistance. With demonstrated efficacy in preclinical and clinical studies, Pocapavir contributes to the development of antiviral strategies aimed at combating enterovirus infections and improving preparedness for emerging and re-emerging viral threats.
| Catalog Number | I008810 |
| CAS Number | 146949-21-5 |
| Synonyms | SCH-48973; SCH48973; SCH 48973; V074; V 073; V-073; Pocapavir.;1,3-dichloro-2-((4-((2-chloro-4-methoxyphenoxy)methyl)benzyl)oxy)benzene |
| Molecular Formula | C21H17Cl3O3 |
| Purity | ≥95% |
| Target | Enterovirus |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | 1,3-dichloro-2-[[4-[(2-chloro-4-methoxyphenoxy)methyl]phenyl]methoxy]benzene |
| InChI | InChI=1S/C21H17Cl3O3/c1-25-16-9-10-20(19(24)11-16)26-12-14-5-7-15(8-6-14)13-27-21-17(22)3-2-4-18(21)23/h2-11H,12-13H2,1H3 |
| InChIKey | XXMDDBVNWRWNCW-UHFFFAOYSA-N |
| SMILES | COC1=CC(=C(C=C1)OCC2=CC=C(C=C2)COC3=C(C=CC=C3Cl)Cl)Cl |
| Reference | </br>1:Antiviral Activity of Pocapavir in a Randomized, Blinded, Placebo-Controlled Human Oral Poliovirus Vaccine Challenge Model. Collett MS, Hincks JR, Benschop K, Duizer E, van der Avoort H, Rhoden E, Liu H, Oberste MS, McKinlay MA, Hartford M.J Infect Dis. 2017 Feb 1;215(3):335-343. doi: 10.1093/infdis/jiw542. PMID: 27932608 Free PMC Article</br>2:First use of investigational antiviral drug pocapavir (v-073) for treating neonatal enteroviral sepsis. Torres-Torres S, Myers AL, Klatte JM, Rhoden EE, Oberste MS, Collett MS, McCulloh RJ.Pediatr Infect Dis J. 2015 Jan;34(1):52-4. doi: 10.1097/INF.0000000000000497. PMID: 25229269 |
