POLA1 inhibitor 1

• CAT Number: I043505
• CAS Number: 2217671-41-3
• Molecular Formula: C26H27NO4
• Molecular Weight: 417.50
• Purity: ≥95%
• Synonyms: (E)-3-[4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-[(E)-hydroxyiminomethyl]phenyl]prop-2-enoic acid
• InChI: InChI=1S/C26H27NO4/c28-24-5-3-20(22-4-1-16(2-6-25(29)30)10-21(22)15-27-31)11-23(24)26-12-17-7-18(13-26)9-19(8-17)14-26/h1-6,10-11,15,17-19,28,31H,7-9,12-14H2,(H,29,30)/b6-2+,27-15+
• InChIKey: PLQNJDDLZLIMNK-DTHWQZMASA-N
• SMILES: C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=C(C=C(C=C5)C=CC(=O)O)C=NO)O

POLA1 inhibitor 1 (Compound 12) is an orally active POLA1 inhibitor. POLA1 inhibitor 1 shows antitumor activity against several tumor histotypes and Adarotene-resistant cell line[1].
POLA1 inhibitor 1 (Compound 12) (15 mg/kg and 50 mg/kg) displays a significantly antitumor effect in HT-29 and MM487 xenografts[1].

Reference

[1]. Cincinelli R, et al. Novel adamantyl retinoid-related molecules with POLA1 inhibitory activity. Bioorg Chem. 2020 Nov;104:104253.
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