Polifeprosan 20

• CAT Number: I034917
• CAS Number: 90409-78-2
• Molecular Formula: C27H34O10
• Molecular Weight: 518.56
• Purity: 98%
• Synonyms: Polifeprosan 20; Polifeprosan; Polifeprosanum.
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 4,4'-(propane-1,3-diylbis(oxy))dibenzoic acid compound with decanedioic acid (1:1)
• InChI: InChI=1S/C17H16O6.C10H18O4/c18-16(19)12-2-6-14(7-3-12)22-10-1-11-23-15-8-4-13(5-9-15)17(20)21;11-9(12)7-5-3-1-2-4-6-8-10(13)14/h2-9H,1,10-11H2,(H,18,19)(H,20,21);1-8H2,(H,11,12)(H,13,14)
• InChIKey: JVYNJRBSXBYXQB-UHFFFAOYSA-N
• SMILES: c1c(ccc(c1)OCCCOc1ccc(cc1)C(=O)O)C(O)=O.C(CCCCCCCCC(=O)O)(O)=O

Polifeprosan 20 is biodegradable polymeric matrix that can be surgically implanted for the interstitial delivery of drugs, such as BCNU, in the brain.

Reference

1: Kleinberg L. Polifeprosan 20, 3.85% carmustine slow release wafer in malignant glioma: patient selection and perspectives on a low-burden therapy. Patient Prefer Adherence. 2016 Nov 24;10:2397-2406. eCollection 2016. Review. PubMed PMID: 27920506; PubMed Central PMCID: PMC5125766.
2: Kleinberg L. Polifeprosan 20, 3.85% carmustine slow-release wafer in malignant glioma: evidence for role in era of standard adjuvant temozolomide. Core Evid. 2012;7:115-30. doi: 10.2147/CE.S23244. Epub 2012 Oct 26. PubMed PMID: 23118709; PubMed Central PMCID: PMC3484478.
3: Glick JA, Graham RS, Voils SA. Candida meningitis post Gliadel wafer placement successfully treated with intrathecal and intravenous amphotericin B. Ann Pharmacother. 2010 Jan;44(1):215-8. doi: 10.1345/aph.1M453. Epub 2009 Dec 22. PubMed PMID: 20028954.
4: La Rocca RV, Mehdorn HM. Localized BCNU chemotherapy and the multimodal management of malignant glioma. Curr Med Res Opin. 2009 Jan;25(1):149-60. doi: 10.1185/03007990802611935 . Review. PubMed PMID: 19210148.
5: Attenello FJ, Mukherjee D, Datoo G, McGirt MJ, Bohan E, Weingart JD, Olivi A, Quinones-Hinojosa A, Brem H. Use of Gliadel (BCNU) wafer in the surgical treatment of malignant glioma: a 10-year institutional experience. Ann Surg Oncol. 2008 Oct;15(10):2887-93. doi: 10.1245/s10434-008-0048-2. Epub 2008 Jul 18. PubMed PMID: 18636295.
6: Weingart J, Grossman SA, Carson KA, Fisher JD, Delaney SM, Rosenblum ML, Olivi A, Judy K, Tatter SB, Dolan ME. Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial. J Clin Oncol. 2007 Feb 1;25(4):399-404. PubMed PMID: 17264335; PubMed Central PMCID: PMC2556256.