For research use only. Not for therapeutic Use.
PolQi2 inhibits the helicase activity of Polθ. PolQi2 improves the precision of gene editing at various loci and in different cell lines[1].
| Catalog Number | I040795 |
| CAS Number | 2565638-16-4 |
| Synonyms | N-[5-[(5-chloropyridin-2-yl)methoxy]-1,3,4-thiadiazol-2-yl]-3-(2-methoxyphenyl)pyridine-4-carboxamide |
| Molecular Formula | C21H16ClN5O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C21H16ClN5O3S/c1-29-18-5-3-2-4-15(18)17-11-23-9-8-16(17)19(28)25-20-26-27-21(31-20)30-12-14-7-6-13(22)10-24-14/h2-11H,12H2,1H3,(H,25,26,28) |
| InChIKey | REZMONWROTVQHG-UHFFFAOYSA-N |
| SMILES | COC1=CC=CC=C1C2=C(C=CN=C2)C(=O)NC3=NN=C(S3)OCC4=NC=C(C=C4)Cl |
| Reference | [1]. imberger S, et al. Simultaneous inhibition of DNA-PK and Polθ improves integration efficiency and precision of genome editing. Nat Commun. 2023 Aug 14;14(1):4761. |
