Polygalacturonic acid

• CAT Number: R068518
• CAS Number: 25990-10-7
• Molecular Formula: (C6H10O7)x
• Purity: ≥95%

Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity[1][2].
Polygalacturonic acid can be used to format a durable hydrogel, to prolong the effect of drugs. Polygalacturonic acid hydrogel/hyaluronate, conjugated Ibuprofen (HY-78131) for example, prevents epidural fibrosis, the severe scar tissue adhesion of laminectomized male adult rats, and increases the efficiency of local inflammation control and reduces the side-effect of Ibuprofen[1].
Polygalacturonic acid hydrogel/hyaluronate (PGA-HA) (2%, 200 μL; 24 h) shows low cytotoxicity on L929 fibroblasts[1].
Polygalacturonic acid (PGA) preparing (Ag-PGA/HA)-PVA nanoparticles, shows anti-bacterial activity against gram-positive bacterial strains; Bacillus Subtilis and Staphylococcus Aureus, as well as gram-negative bacterial strain; Escherichia Coli[2].
Polygalacturonic acid (external application; 14 d) enhances a quick healing of wound infection in albino rats[2].

Reference

[1]. Lin CY, et al. Ibuprofen-conjugated hyaluronate/polygalacturonic acid hydrogel for the prevention of epidural fibrosis. J Biomater Appl. 2016 May;30(10):1589-600.
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[2]. El-Aassar MR, et al. Wound healing of nanofiber comprising Polygalacturonic/Hyaluronic acid embedded silver nanoparticles: In-vitro and in-vivo studies. Carbohydr Polym. 2020 Jun 15;238:116175. 
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