Polyinosinic-polycytidylic acid sodium

• CAT Number: I016843
• CAS Number: 42424-50-0
• Molecular Formula: (C₁₀H₁₃N₄O₈P)x.(C₉H₁₄N₃O₈P)x.xNa
• Purity: ≥95%
• Target: Apoptosis
• InChI: 1S/C10H13N4O8P.C9H14N3O8P.Na/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18);/t4-,6-,7-,10-;4-,6-,7-,8-;/m11./s1
• InChIKey: GETQKWBYQAUFQM-VRQAYDGLSA-N
• SMILES: C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O.C1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O.[Na]

Polyinosinic-polycytidylic acid sodium (CAT: I016843), a synthetic analog of double-stranded RNA, functions as an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). It has multiple immunomodulatory effects and can be utilized as a vaccine adjuvant to enhance innate and adaptive immune responses. Additionally, Polyinosinic-polycytidylic acid sodium has been shown to induce apoptosis directly in cancer cells. In vitro, studies demonstrate that treatment with Polyinosinic-polycytidylic acid sodium reduces cell viability and induces apoptosis in various cancer cell lines. It also induces the expression of IFN-β, a key cytokine involved in antiviral and antitumor immune responses, through the activation of RIG-I and MDA-5. Moreover, Polyinosinic-polycytidylic acid sodium exhibits tumor growth inhibition in animal models. Proper preparation of Polyinosinic-polycytidylic acid sodium for injection involves solubilization and annealing of the double-stranded RNA.