Polymyxin B sulphate

• CAT Number: A000641
• CAS Number: 1405-20-5
• Molecular Formula: C56H98N16O13.H2SO4
• Molecular Weight: 1301.56
• Purity: ≥95%
• Synonyms: Aerosporin, PMB, Poly-RX
• Target: Bacterial
• Storage: -20°C
• Related CAS: 4135-11-9 (free base)
• IUPAC Name: N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acid
• InChI: InChI=1S/C56H98N16O13.H2O4S/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79;1-5(2,3)4/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80);(H2,1,2,3,4)
• InChIKey: HFMDLUQUEXNBOP-UHFFFAOYSA-N
• SMILES: CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O

Polymyxin B Sulphate（Cat No.:A000641）is an antibiotic primarily effective against gram-negative bacteria, including Pseudomonas aeruginosa and Escherichia coli. It disrupts the bacterial cell membrane by interacting with phospholipids, leading to cell leakage and death. Widely used in treating infections resistant to other antibiotics, Polymyxin B Sulphate is also crucial in research for studying membrane-targeted antibacterial mechanisms and multidrug-resistant pathogens. Its potent action makes it a valuable compound in developing treatment options for severe infections and enhancing understanding of bacterial cell wall vulnerabilities and antibiotic resistance.