Pomalidomide

• CAT Number: A000692
• CAS Number: 19171-19-8
• Molecular Formula: C13H11N3O4
• Molecular Weight: 273.2
• Purity: ≥95%
• Synonyms: 19171-19-8; 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; Actimid; Pomalyst; CC-4047
• Target: TNF-α
• Solubility: >7.5mg/mL in DMSO
• Storage: -20°C
• IUPAC Name: 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
• InChI: 1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
• InChIKey: UVSMNLNDYGZFPF-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)N

Pomalidomide (CAS 19171-19-8), also known as CC4047, is an orally bioavailable derivative of thalidomide with potential immunomodulating, antiangiogenic and antineoplastic activities. Although its exact mechanism of action has yet to be fully elucidated, pomalidomide appears to inhibit TNF-alpha production, enhance the activity of T cells and natural killer (NK) cells and enhance antibody-dependent cellular cytotoxicity (ADCC). Pomalidomide was approved on February 8, 2013 as a treatment for relapsed and refractory multiple myeloma.

Overview of Clinical Research

Pomalidomide is an angiogenesis inhibitor and an immunomodulator developed by Celgene Corporation. Amgen initiates phase II select trial for multiple myeloma therapy in USA, Spain, Denmark, Greece, Italy and Germany. 

Reference

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