Pomalidomide-C6-O-C5-O-C4-COOH

• CAT Number: I042620
• CAS Number: 2375774-54-0
• Molecular Formula: C29H41N3O8
• Molecular Weight: 559.65
• Purity: ≥95%
• Synonyms: 5-[5-[6-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]hexoxy]pentoxy]pentanoic acid
• InChI: InChI=1S/C29H41N3O8/c33-24-15-14-23(27(36)31-24)32-28(37)21-11-10-12-22(26(21)29(32)38)30-16-5-1-2-6-17-39-18-7-3-8-19-40-20-9-4-13-25(34)35/h10-12,23,30H,1-9,13-20H2,(H,34,35)(H,31,33,36)
• InChIKey: STEWOGZNWZMCIJ-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCCCCCOCCCCCOCCCCC(=O)O

Pomalidomide-C6-O-C5-O-C4-COOH is a E3 ligase ligand-linker conjugate comprising a Pomalidomide (HY-10984)-based cereblon ligand and linker. Pomalidomide-C6-O-C5-O-C4-COOH can be used for the synthesis of PROTACs[1].

Reference

[1]. Steinebach C , et al. PROTAC-mediated crosstalk between E3 ligases. Chem Commun (Camb). 2019 Feb 5;55(12):1821-1824.
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